Adaptive dynamics of extrachromosomal circular DNA in rice under nutrient stress
Artículo
Te invitamos a leer el artículo "Adaptive dynamics of extrachromosomal circular DNA in rice under nutrient stress" publicado en Nature a cargo del profesor investigador Dr. Luis Rafael Herrera Estrella y su equipo de trabajo de la UGA.
Autores: Hanfang Ni / Lenin Yong-Villalobos / Mian Gu / Damar Lizbeth López-Arredondo / Min Chen / Liyan Geng / Guohua Xu / Luis Herrera-Estrella
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National Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Nanjing Agricultural University, Nanjing, China
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MOA Key Laboratory of Plant Nutrition and Fertilization in Lower-Middle Reaches of the Yangtze River, Nanjing, China
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Department of Plant and Soil Science, Institute of Genomics fo rCrop Abiotic Stress Tolerance (IGCAST), Texas Tech University, Lubbock, TX,USA
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Unidad de Genómica Avanzada (UGA) del Centro de Investigación y de Estudios Avanzados (Cinvestav) del Instituto Politécnico Nacional, Irapuato, Guanajuato, Mexico
Felicitamos al estudiantado y profesorado que contribuyeron en esta investigación por su arduo trabajo.
Summary:
Extrachromosomal circular DNAs (eccDNAs) have been identified in various eukaryotic organisms and are known to play crucial roles in genomic plasticity. However, in crop plants, the role of eccDNAs in responses to environmental cues, particularly nutritional stresses, remains unexplored. Rice (Oryza sativa ssp. japonica), a vital crop for over half the world’s population and an excellent model plant for genomic studies, faces numerous environmental challenges during growth. Therefore, we conduct comprehensive studies investigating the distribution, sequence, and potential responses of rice eccDNAs to nutritional stresses. We describe the changes in the eccDNA landscape at various developmental stages of rice in optimal growth. We also identify eccDNAs overlapping with genes (ecGenes), transposable elements (ecTEs), and full-length repeat units (full-length ecRepeatUnits), whose prevalence responds to nitrogen (N) and phosphorus (P) deficiency. We analyze multiple-fragment eccDNAs and propose a potential TE-mediated homologous recombination mechanism as the origin of rice’s multiple-fragment eccDNAs. We provide evidence for the role of eccDNAs in the rice genome plasticity under nutritional stresses and underscore the significance of their abundance and specificity.